Researchers from Japan and Indonesia reported in a study how an experimental drug agent, based on an analogue of a molecule found in turmeric, showed significant anti-cancer effects.
The active substance, pentagamavumon-1 (PGV-1), was observed to inhibit a series of enzymes responsible for the metabolism of reactive oxygen species. The results suggested PGV-1 was effective on numerous types of cancers with minimal side effects. Furthermore, it was noted that unlike other anti-cancer drugs, the anti-cancer effects persisted even after the cessation of PGV-1 administration.
The authors of the study also note a similar behaviour from natural turmeric.
“Our results suggest that PGV-1 inhibits the enzyme activity more effectively in cancer cells than in normal cells. This may be the reason why PGV-1 selectively suppresses tumor cell proliferation with few effects on normal cells” noted Professor Jun-ya Kato, co-author of the study.
The study was conducted at the Nara Institute of Science and Technology.
Read more: Stressing cancer with spice — ScienceDaily
Photo Credit: @andy_hyd on Unsplash.com
Scientific References
[1] Lestari B, Nakamae I, Yoneda-kato N, et al. Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence. Sci Rep. 2019;9(1):14867.
Your opinion will be posted on our website. You can enter your data or report it anonymously, without providing your name, please fill out your gender and age, it will help to give your opinion better. Thank you!
