Description
Our NeurotropEx™ is a botanical formula harnessing the powers of coffee berries & Scutellaria baicalensis extracts to support your cognitive health:*
- It can promote the reparation and regeneration of nerve & brain tissue*
- It could be beneficial for your cognitive functionality & short term memory*
To our knowledge, not many botanicals have been shown to:
- Increase neurotrophic factors such as BDNF by 143% [1]
- Prevent amyloid accumulation – and dissolve – already present amyloid plaque
- Provide day-to-day fuel for neural mitochondria & boost general cognition
We have therefore chosen two which the scientific community believes are up for the job: Scutellaria baicalensis (commonly known as Skullcap) and extract from coffee berries & and enhanced by MCT from coconut oil.
What Does Our NeurotropEx™ Formula Contain?
Our NeurotropEx™ formula consists of:
- Coffee berry extract (standardized to 2% polyphenols) – 400 mg
- MCT powder (powderized coconut oil) – 200 mg
- Scutellaria baiclensis (skullcap root extract, standardized to 90% baicalin) – 50mg
It comes in a vegan-friendly cellulose capsule.
Like our other nutraceuticals, our NeurotropEx™ formula is free from allergens such as gluten, soy, fish, lactose, milk, meat and wheat.
What Is the Recommended Daily Dosage?
We recommend 2 capsules, twice a day or as advised by your healthcare professional. It can be consumed with meals.
What Does the Science Say?
Coffee berry fruit
BDNF is one of the most potent neurotrophic factors, keeping brain neurons and its connections (synapses) in the best performing state. Research suggests that coffee berries boost BDNF by up to 143% [1] and that diminishing levels of BDNF may be associated with neurodegeneration and depression.
Scutellaria baicalensis
Skullcap (Scutellaria baicalensis) is rich in baicalin and baicalein. These flavonoids cross the blood/brain barrier and accumulate in its structures associated with the preservation of memory, learning (like the Hippocampus) and motor function [2,3,13]. Studies suggest that baicalin can protect neurons from negative influence of low oxygen (hypoxia) and other toxins as well as prolong their life in the hippocampal area [2,3,4,5,10].
MCT Oil Powder
Medium Chain Triglycerides from coconut oil provide mitochondrial fuel and have been shown to boost cognition in humans [17,18].
Scientific References & Relevant Research
[1] Reyes-Izquierdo T, Nemzer B, Shu C, et al. Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition. 2013;110(3):420-425. doi:10.1017/s0007114512005338.
[2] Zhao WZ, Wang HT, Huang HJ, Lo YL, Lin AM. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain. Mol Neurobiol. 2018;55(1):130-137
[3] Zhang X, Du L, Zhang W, Yang Y, Zhou Q, Du G. Therapeutic effects of baicalein on rotenone-induced Parkinson’s disease through protecting mitochondrial function and biogenesis. Sci Rep. 2017;7(1):9968.
[4] Rodriguez I, Hong BN, Nam YH, et al. Bioconversion of Scutellaria baicalensis extract can increase recovery of auditory function in a mouse model of noise-induced hearing loss. Biomed Pharmacother. 2017;93:1303-1309.
[5] Huang DS, Yu YC, Wu CH, Lin JY. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway. Evid Based Complement Alternat Med. 2017;2017:3545169.
[6] Li Y, Zhao J, Hölscher C. Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease. CNS Drugs. 2017;31(8):639-652.
[7] Zhang X, Yang Y, Du L, Zhang W, Du G. Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats. Int Immunopharmacol. 2017;50:38-47.
[8] Lim HS, Kim OS, Kim BY, Jeong SJ. Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. J Med Food. 2016;19(11):1032-1040.
[9] Hung KC, Huang HJ, Wang YT, Lin AM. Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP-treated nigrostriatal dopaminergic system in vivo. J Ethnopharmacol. 2016;194:522-529.
[10] Zhao Q, Chen XY, Martin C., the golden herb from the garden of Chinese medicinal plants. Sci Bull (Beijing). 2016;61(18):1391-1398.
[11] Li XL, Xu XF, Bu QX, et al. Effect of total flavonoids fromon dopaminergic neurons in the substantia nigra. Biomed Rep. 2016;5(2):213-216.
[12] Chang Y, Lu CW, Lin TY, Huang SK, Wang SJ. Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats. Am J Chin Med. 2016;44(5):943-62.
[13] Zhang L, Xing D, Wang W, Wang R, Du L. Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. J Ethnopharmacol. 2006;103(1):120-5.
[14] Gu XH, Xu LJ, Liu ZQ, et al. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease. Behav Brain Res. 2016;311:309-321.
[15] Heo H, Shin Y, Cho W, Choi Y, Kim H, Kwon YK. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. J Ethnopharmacol. 2009;122(1):20-7.
[16] Huang H, Zhang Y, Yang R, Tang X. Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;874(1-2):77-83.
[17] Hertz L, Chen Y, Waagepetersen HS. Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function. J Neurochem. 2015;134(1):7-20.
[18] Rebello CJ, Keller JN, Liu AG, Johnson WD, Greenway FL. Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial. BBA Clin. 2015;3:123-5. Result: Intake of MCT Oil Increased Serum Ketone Bodies and Improved Memory While Intake of Placebo Did Not Show Improvements in Any Cognitive Measure Tested.
