Description
A-Biotic™ is composted to support the body’s natural defence mechanisms against microbes. It is a powerful anti-microbial combination of five herbal extracts – such as Andrographis paniculata – known for centuries as natural antibiotic and antiviral agents.*
What Does Our A-Biotic™ Formula Contain?
Our A-Biotic™ formula is made up of the following ingredients, described in more detail below:
- Andrographis paniculata leaf extract – 158 mg
- Coptis chinensis root extract – 131 mg
- Ziziphus jujuba fruit extract – 53 mg
- Zingiber officinale rhizome extract – 27mg
- Isatis tinctoria root extract – 131mg
The capsules are made from cellulose and are suitable for vegans.
Like our other nutraceuticals, our A-Biotic™ is free from allergens such as gluten, soy, fish, lactose, milk, meat and wheat.
What Is the Recommended Daily Dosage?
We recommend 1 capsule per day or as advised by your healthcare professional. It can be consumed with meals.
What Does the Science Say?
Andrographis Paniculata
Andrographis Paniculata (Chuan Xin Lian) is a a well-known herb in TCM for treatment of large number of ailments including: fever, infections, diabetes, influenza, malaria, skin diseases and many more.
Andrographis contains many compounds exhibiting powerful medicinal properties. Among these are Terpenoids (entalbdane diterpene lactones), flavones, iridoids, xanthones, polyphenols and other micro and macro elements. One of the most abundant diterpenoids found in Andrographis is Androgropholide, though others include Deoxyandrographolide and Neoandrographolide, Isoandrographolide, andrographanin.
Many studies conducted by Asian scientists validated andrographis paniculata’s therapeutic properties. Dry herb water extract of Andropgrapolides and arabinogalctan proteins showed strong anti-bacterial activity against Baccilus subtilis, Escherichia Coli, Pseudomonas aeruginosa and Candida albicans. Andrographanin extracted from andrographis paniculata leaves inhibited NO and pro-inflammatory cytokins (TNF alpha, IL-6, IL-12p70) in a dose dependent manner.
Coptis Chinensis
The rhizome of Chinese goldthread (Coptis chinensis rhizoma, Huang Lian) has been used for centuries and up to the present day in TCM as an antimicrobial agent. TCM uses Coptis rhizoma for the treatment of a variety of bacterial and viral infections, especially those exhibiting a high fever (in TCM, it is considered one of the most effective heat-clearing herbs).
Coptis rhizoma has traditionally been used in treating and support against:
- Cold & flu
- Upper respiratory and pulmonary infections
- Gastroenteritis
- Bacillary dysentery
- Pertussis
- Eczema
- Hepatitis
Modern clinical research studies have demonstrated Coptis’s efficacy against bacteria, viruses, protozoans, helmets and chlamydia. Particular examples include Staphylococcus aureus, Pseudomonas aeruginasae, E. Coli, Propionibacterium, acnes, Staphylococus, pneumonia, Vibrio cholerae, Bacillus anthracis, Bacillus dysenteriae, cold, flu and Hepatitis C viruses [1,2].
Coptis chinensis is a source of Berberine. Clinical studies observed Berberine to be a powerful regulator (and supporter) of glucose and lipids, helping to keep them at the right level within the body. It is believed these positive effects can be attributed to Berberine’s positive effect on intestinal microbiota [5].
Other studies have shown that Coptis (Berberine) contributed to decreased Hemoglobin A1C levels and normalisation of the hepatic fat metabolism [3].
Ziziphus Jujuba
Ziziphus Jujuba is a fleshy fruit that has many health benefits.
A study published in the Journal of Agricultural and Food Chemistry indicated that Jujuba fruit consumption can improve the gastrointestinal environment and reduce exposure of gastrointestinal mucosa to harmful and irritable compounds[7].
ZIziphus Jujuba contains high levels of Vitamin C and Potassium. It could therefore be beneficial for heart and vascular health by work as a “gentle” vasodilator by promoting healthy blood pressure and microcirculation.
Zingiber Siccatum
Ginger (Zingiber siccatum, Gan Jiang heat-processed extract of Zingiber officinalae) is a powerful compound used for centuries in TCM for the treatment of (among others):
- Infections
- Gastrointestinal disorders
- Food poisoning
- Dizziness
- Diarrhea
Furthermore, Ginger is rich in two important phytochemicals: Gingerone-A and Shogaol.
Clinical trials have demonstrated that ginger can have powerful antibacterial properties, for example in inhibiting the proliferation of MRSa (Methycyllin-Resistant Staphylococus aureus) through the inhibition of the SaHPPIC (Staphylococcus aureus 6Hydroxymethyl-7-8 dihydropterin) enzyme [10]. This enzyme is essential for the docking of bacteria on cells’ memberane’s and thus their further proliferation.
The presence of ginger not only enhances A-Biotic’s anti-bacterial, anti-viral and detoxifying properties but also balances the cold nature of Andrographis and Coptis, thus optimizing the formula’s gastrointestinal tolerance.
Isatis Tinctoria
Isatis Tinctoria root (Ban Lan Gen) is used in TCM as an herbal antibiotic and antiviral agent. In TCM, Isatis is used to clear the toxic heat from bacterial and viral infections. Isatis contains several alkaloids – notably Tryptanthrin and Indirubin – that make it a powerful healing agent.
Scientific References & Relevant Research
[1] Muluye RA, Bian Y, Alemu PN. Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs: A Current Review. J Tradit Complement Med. 2014;4(2):93–98. doi:10.4103/2225-4110.126635
[2] Hung TC, Jassey A, Lin CJ, et al. Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection. Viruses. 2018;10(12):669. doi:10.3390/v10120669
[3] Han J, Lin H, Huang W. Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit. ;17(7):RA164–RA167. doi:10.12659/msm.881842
[4] Auyeung KK, Ko JK. Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. Int J Mol Med. 2009;24(4):571-7.
[5] Zhang Q, Piao XL, Piao XS, Lu T, Wang D, Kim SW. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem Toxicol.2011;49(1):61-9.
[6] Zhen Z, Chang B, Li M, et al. Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats. Am J Chin Med. 2011;39(1):53-63.
[7] Huang YL, Yen GC, Sheu F, Chau CF. Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices. J Agric Food Chem. 2008;56(5):1734-9.
[8] Danz H, Stoyanova S, Wippich P, Brattström A, Hamburger M. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Med. 2001;67(5):411-6.
[9] Hartleb I, Seifert K. Acid constituents from Isatis tinctoria. Planta Med. 1995;61(1):95-6.
[10] Rampogu S, Baek A, Gajula RG, et al. Ginger (Zingiber officinale) phytochemicals-gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches. Ann Clin Microbiol Antimicrob. 2018;17(1):16. Published 2018 Apr 2. doi:10.1186/s12941-018-0266-9
[11] Ma MZ, Yao BY. Progress in indirubin treatment of chronic myelocytic leukemia. J Tradit Chin Med. 1983;3(3):245-8.
[12] Bensky D, Gamble A, Kaptchuk TJ. Chinese Herbal Medicine, Materia Medica. Seattle, WA: Eastland Press;1986.
[13] Bensky D, Gamble A, Kaptchuk TJ. Chinese Herbal Medicine, Materia Medica (Revisited Edition). Seattle, WA: Eastland Press;1993:95.
[14] Singh PK, Farnsworth NR, Soejarto DD. Global importance of medicinal plants. In: Akerlev O, Heywood V, Synge H (ed). The conservation of medicinal plants.Cambridge: Cambridge University Press;1999:125-512
[15] Balu S, Alagesaboopathi C. Anti-inflammatory activities of some species of andrographis wall. (Acanthaceae). Anc Sci Life. 1993;13(1-2):180–184.
[16]Singha PK, Roy S, Dey S. Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. J Ethnopharmacol. 2007;111(1):13-21.
[17]Singha PK, Roy S, Dey S. Antimicrobial activity of Andrographis paniculata. Fitoterapia. 2003;74(7-8):692-4.
