NO MAXX Salvia miltiorrhiza radix 100 mg Prunella Spica 250mg Notoginseng Radix 100mg Ziziphus Jujuba 50mg FOR HEALTHY HEART AND BRAIN
v potent botanical extracts combination supporting healthy level of endothelial NO / nitric oxide/ and supporting healthy state of blood vessels in heart and brain/ ref 4, 6, 8, 11, v potent cardioprotective herbal combination assist in reducing cardiovascular oxidative stress /ref 2, 7, 9/*
v supports cerebrovascular health in stroke prevention / ref 4/*
v supports healthy cognition via inhibition of Acetylcholinesterase enzyme /ref 1
1. SALVIA MILTIORRHIZA root /ref
*These statements have not been evaluated by the FDA.
Referred to as “Danshen” has been used for hundreds of years in treatment of Cardiovascular diseases in Traditional Chinese Medicine and traditionally has been used for heart disease and ischemic stroke. It is regarded as “activating circulation and dispersing stasis or sludging of blood” type of herb. In TCM Danshen is the most frequently prescribed single herb for hypertension. Modern research shows that Salvia miltiorrhiza exhibits strong antioxidant activity by scavenging ROS /ref 2 /, inhibits platelet aggregation , and protects endothelial cells against homocysteine-induced endothelial dysfunction / ref 3/. in animals studies Salviaʼs Tan II A / one of the active ingredients/ elicits strong vasodilatory effect in coronary arterioles, increased NO /ref 4, 6/ New studies show it may assist patients with diabetes as tanshinones / active ingredients in Danshen / are insulin sensitiizers , and in animal studies were shown to attenuate insulin resistance through increases in the activities of catalase , MnSOD, and glutathione peroxidase /ref 5 / Salvia miltiorrhiza was shown in research to inhibit the enzyme responsible for Acetylocholine degradation / one of many factors responsible for cognitive decline in old age / assissting in maintenance of higher levels of Acetylocholine in brain helping memory and cognition /ref 1/ Danshen was found to increase eNOS promoter activity,eNOSmRNA protein expression, as well as endothelial NO production, extract contains high level of polyphenolic compounds with antioxidants properties. This may prevent BH4 oxidation and eNOS un-coupling./ ref 8/
2. PRUNELLA VULGARIS .PVL is used in TCM as well as in Western herbal medicine. In the West, the plant has been used primarily as a remedy to alleviate pains in the throat, to treat fevers and to accelerate wound healing. Modern pharmacological studies have revealed a wide array of biological effects and numerous therapeutic possibilities for the herb, including anti-viral and anti-bacterial effects, immunomodulatory, anti-allergy and anti-cancer potential, as well as antioxidant activity .. It is also commonly used as a component in combination therapy for hypertension. In animal studies Intravenous injection of PVL saponins results in a reduction of both systolic and diastolic blood pressures . New studies demonstrated that PVL is an effective eNOS-upregulating herb; it signiﬁcantly increases eNOS promoter activity, eNOS mRNAand protein expression and NO production in human endothelial cells [ ref 8]. PVL extracts contain a variety of chemical constituents, including triterpenoids (such as ursolic acid, betulinic acid, oleanolic acid, vulgarsaponins), ), ﬂavonoids (such as rosmarinic acid, luteolin, cynaroside,homoorientin, quercetin), coumarins (such as umbelliferone, scopoletin, esculetin), organic acids (such as caffeic acid, palmitic acid, stearic acid, oleic acid, arachidic acid, lauric acid,myristic acid), sugars, as well as essential oils . New studies have demonstrated that ursolic acid (also present in Salviae miltiorrhizae radix [ref 8], betulinic acid (also a constituent ofZizyphi spinosae semen [ref 8], luteolin and cynaroside (alsoconstituents of artichoke,Cynara scolymus L.)[ref 8] are eNOS-upregulating compounds.
3. ZIZIPHUS SPINOSAE semen (ZSS) This plant has been used in Oriental medicine for its sedative and hypnotic herb with additional effects on the cardiovascular system. In animal studies ZSS protected cardiomyocytes from ischemic injury, supported proper tone in blood vessels, helping to maintain normal blood pressure /ref 8/ It was found that ZSS increases eNOS promoter activity,eNOS mRNA and protein expression, as well asNO production in human endothelial cells, /ref 8/ 4. PANAX NOTOGINSENG RADIX This plant known as TianQi with its active ingredient saponins / PNS/ has wideranging pharmacological effects and has been used in TCM to treat cardiovascular diseases, pain, inﬂammation, trauma , external and internal bleeding. It has a protective effect on blood vessels, supports platelet anti-aggregation mechanisms as shown in animal studies/ ref11/ Recent animal studies show that Notoginseng, in addition to his vasodilation effects through its effect on nitric oxide production , has a potential to protect neurons from oxidative damage, via the attenuating the production of 8-OHdG and enhancing the activity of important anti-oxidant enzymes , increasing levels of SOD/ superoxide dismutase / , CAT / Catalase/ and GSH-PX / Glutathione peroxidase/ in brain, PNS prevented neuronal loss in hippocampal region /responsible for memory/ and even was able to alleviate pathophysiological changes in neurons / ref 9/
Recent studies show it may have positive effect on support glucose metabolism /ref10/
1.Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorrhiza RenY, HoughtonPJ PMID 15114495 pubmed Acetylcholinesterase (AChE, EC 22.214.171.124) inhibitors are the only registered drugs used to treat Alzheimer’s disease (AD). New AChE inhibitors may contribute to the design of new pharmaceuticals and supply information which will facilitate the understanding of the interaction between inhibitors and the enzyme. The dried root of Salvia miltiorhiza is called ‘Danshen’ in China, and has been used for the treatment of cerebrovascular disease and CNS deterioration in old age for over one thousand years. In this work, a modiﬁed Ellman method was used to guide the fractionation of the active AChE inhibitor compounds from an acetone extract. Four inhibitory compounds, dihydrotanshinone, cryptotanshinone, tanshinone I and tanshinone IIA were isolated, and the structures were identiﬁed by comparison of their spectral characteristics with previous reports. The inhibitory activities of dihydrotanshinone and cryptotanshinone were dose-dependent, their IC (50) values being 1.0 microM and 7.0 microM, respectively. These two compounds were the major inhibitory compounds in the extract as judged by HPLC analysis, forming 0.054 % w/w and 0.23 % w/w in the dried root, respectively, and in mixture they appear to be less active than as isolated compounds. The clogP values of dihydrotanshinone, cryptotanshinone, tanshinone I and tanshinone IIA were calculated as 2.4, 3.4, 4.8 and 5.8, respectively, which indicate that these compounds have potential to penetrate the blood-brain barrier. This is the ﬁrst example of diterpenoids as inhibitors of AChE. 2.Fu.J, Huang H Liu J et all Tianshinone IIA protect cardiac myocytes against oxidative stress-triggered damage and apoptosis European Journal of Pharmacology 2007, 3.Chan K, ChuiS. H, Wong D.Y.L. Protective effects of Danshen from the aqueous extract of Salvia miltiorrhiza / Danshen/ against homocysteine-induced endothelial dysfunction . Life Sciences , 2004 ;75(26) 3157-3171 4. The American Journal of Chinese Medicine Vol. 38 issue 03,2010 Ning Xia et all “.The purported effects of “circulation-improving” herbs used in traditional Chinese medicine (TCM) show striking similarities with the vascular actions of nitric oxide (NO) produced by the endothelial NO synthase (eNOS). We have previously reported that
Salviae miltiorrhizae radix and Zizyphi spinosae semen upregulate eNOS expression. In the present study, we studied the effect on eNOS gene expression of 15 Chinese herbs with potential effects on the vasculature, and identiﬁed Prunella vulgaris L. (PVL) (ﬂowering spike) as a potent eNOS-upregulating agent. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVEC), an aqueous extract of PVL increased eNOS promoter activity, eNOS mRNA and protein expressions, as well as NO production in concentration- and time-dependent manners. We have previously shown that ursolic acid (a constituent of Salviae miltiorrhizae radix), betulinic acid (a compound present in Zizyphi spinosae semen), luteolin and cynaroside (ingredients of artichoke, Cynara scolymus L.) are capable of enhancing eNOS gene expression. These compounds are also present in signiﬁcant quantities in PVL. Thus, PVL contains active principles that stimulate human eNOS gene expression, and such compounds may have therapeutic potential against cardiovascular diseases.” 5.ZhangW, Zheng L, Zhang Z, Hai C.-X. Protective effect of the water-soluble polysaccharide from Salvia miltiorrhiza Bunge on insuline resistance in rats Carbohydrate Polymers 2012, 89(3) 890-898 PubMed 6. Wu B. G. Zhou E. X. Qing D.X. Tanshinone II (A) elicited vasodilation in rat coronary arteriole , roles of nitric oxide and potassium channels . European Journal of Pharmacology, 2009;617 (1-3) 102-107 PubMed 7.The American Journal of Chinese Medicine , January 2012 Anti-Diabetic Atherosclerosis Effect of Prunella Vulgaris in db/db mice with Type 2 Diabetes , Sun Mi Hwang , Jim Sook Kim “Diabetes mellitus is the leading cause of vascular complications such as atherosclerosis. This study was designed to investigate whether Prunella vulgaris (APV) would inhibit diabetic atherosclerosis in db/db mice with type 2 diabetes. The db/db mice were treated with high fat/high cholesterol (HFHC) diet and an aqueous extract of
APV (100 and 200 mg/kg/day) for eight weeks to examine the long-term effect on metabolic abnormalities and diabetic atherosclerosis. APV treatment markedly lowered blood glucose and systolic blood pressure. The db/db mice experienced an increase in blood urea nitrogen as well as a decrease of creatinine clearance, the latter of which was restored by treatment with APV. Treatment with APV markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol and also increased the HDLcholesterol. In addition, malondialdehyde and TGF-β1 were decreased by treatment of APV. On the other hand, total NO level was decreased in db/db mice. However, the NO level was increased by treatment with APV, suggesting an association with vascular dysfunction. Vascular relaxation of aortic rings by acetylcholine or SNP-inducement was ameliorated by APV in a dose-dependent manner. Damage of vascular intima and hypertrophic of media were observed in db/db mice; however its dysfunction was improved by the treatment of APV. APV treatment signiﬁcantly reduced the aortic expressions of ICAM-1, VCAM-1, ET-1, and nitrotyrosine. Furthermore, expression of
eNOS in aortic was remarkably increased by APV treatment. Taken together, APV suppressed hyperglycemia 8.Huige LI, Effect of Vasoactive Chinese Herbs on the Endothelial NO systems, Recent Advances in Theory and Practice of Chinese Medicine , January 2012 9.Jian-Lan Huang, Xin Jing , Xin Tian Neuroprotective Properties of Panax Notoginseng saponins via PreventingOxidative Stress Injury in SAMP8 mice Evidence Based Complementary and Alternative Medicine January 30,2017 10.Urayisenga R, Ayeka PA, Wang Y Anti-diabetic potential of Panax Notoginseng saponins/PNS/ Phytotherapy Research 2014, April(4) 11.Yanyan Wang, Yu Ren Endothelium dependent vasodilation effect of Panax Notoginseng and its main components are mediated by nitric oxide and cycloxygenase pathways Experimental and Therapeutic Medicine , 2016 December 12(6) PMCID PMC 5228079