NeurotropEx (Cognitive Support)

$34.00

100 Capsules

Dietary Supplement

100 Capsules

Uses:

Supports cognitive health and regeneration of brain and nerve tissue.*

*These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure or prevent and disease.

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Description

NeurotropEx

Our NeurotropEx is a botanical cognitive support formula harnessing the powers of three botanicals:

  • It can promote the reparation and regeneration of  nerve & brain tissue
  • It could be beneficial for your cognitive functionality & short term memory

Our NeurotropEx formula consists of:

Coffee berry extract (Standard to 2% Polyphenols) – 400 mg
Medium Chain Triglycerides Powder (from coconut oil) – 200 mg
Scutellaria baiclensis (Skull Cap Root Extract, standard to 90% baicalin) – 50mg

A Trident of Herbal Power

To our knowledge, not many botanicals have been shown to:

  • Increase neurotrophic factors such as BDNF by 143% [1]
  • Prevent amyloid accumulation and dissolve already present  amyloid plaque
  • Provide day-to-day fuel for neural mitochondria & boost general cognition

We have therefore chosen three which the scientific community believes are up for the job: Scutellaria baicalensis (commonly known as Skullcap) enhanced with extract from coffee berries & MCT from coconut oil.

BDNF Boost

BDNF is one of the most potent neurotrophic factors,

keeping brain neutrons and its connections (synapses) in the best performing state. Research suggests that coffee berries boost BDNF by up to 143% [1] and that diminishing levels of BFNF may be associated with neuro-degeneration.

Away With the Amyloid

Scutellaria baicalensis is rich in baicalin and baicalein. These flavonoids are absorbable by the brain and accumulate in its structures associated with the preservation of memory, learning and motor function (like the Hippocampus) [2,3,13]. Studies suggest that baicalin can a) protect neurons from negative influence of low oxygen (hypoxia) and other toxins affecting them and b) prolong the life of neurons in the hippocampal area [2,3,4,5,10].

MCT Motor

Medium Chain Triglycerides from coconut oil provide mitochondrial fuel and have been shown to boost cognition in humans [1].

 

Scientific References & Relevant Research

[1]  Reyes-Izquierdo T, Nemzer B, Shu C, et al. Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition. 2013;110(3):420-425. doi:10.1017/s0007114512005338.

[2] Zhao WZ, Wang HT, Huang HJ, Lo YL, Lin AM. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain. Mol Neurobiol. 2018;55(1):130-137

[3] Zhang X, Du L, Zhang W, Yang Y, Zhou Q, Du G. Therapeutic effects of baicalein on rotenone-induced Parkinson’s disease through protecting mitochondrial function and biogenesis. Sci Rep. 2017;7(1):9968.

[4] Rodriguez I, Hong BN, Nam YH, et al. Bioconversion of Scutellaria baicalensis extract can increase recovery of auditory function in a mouse model of noise-induced hearing loss. Biomed Pharmacother. 2017;93:1303-1309.

[5] Huang DS, Yu YC, Wu CH, Lin JY. Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway. Evid Based Complement Alternat Med. 2017;2017:3545169.

[6] Li Y, Zhao J, Hölscher C. Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease. CNS Drugs. 2017;31(8):639-652.

[7] Zhang X, Yang Y, Du L, Zhang W, Du G. Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats. Int Immunopharmacol. 2017;50:38-47.

[8] Lim HS, Kim OS, Kim BY, Jeong SJ. Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. J Med Food. 2016;19(11):1032-1040.

[9]  Hung KC, Huang HJ, Wang YT, Lin AM. Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP-treated nigrostriatal dopaminergic system in vivo. J Ethnopharmacol. 2016;194:522-529.

[10]  Zhao Q, Chen XY, Martin C., the golden herb from the garden of Chinese medicinal plants. Sci Bull (Beijing). 2016;61(18):1391-1398.

[11]  Li XL, Xu XF, Bu QX, et al. Effect of total flavonoids fromon dopaminergic neurons in the substantia nigra. Biomed Rep. 2016;5(2):213-216.

[12]  Chang Y, Lu CW, Lin TY, Huang SK, Wang SJ. Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats. Am J Chin Med. 2016;44(5):943-62.

[13]  Zhang L, Xing D, Wang W, Wang R, Du L. Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. J Ethnopharmacol. 2006;103(1):120-5.

[14]  Gu XH, Xu LJ, Liu ZQ, et al. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease. Behav Brain Res. 2016;311:309-321.

[15]  Heo H, Shin Y, Cho W, Choi Y, Kim H, Kwon YK. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. J Ethnopharmacol. 2009;122(1):20-7.

[13]  Huang H, Zhang Y, Yang R, Tang X. Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;874(1-2):77-83.