Joint Formula (Healthy Joints)

$30.00

100 Capsules

Dietary Supplement

Uses:

Support for healthy joints*

*These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure or prevent and disease.

Category:

Description

JOINT FORMULA
D Glucosamine Sulfate 413.5mg
Chondroitin Sulfate Sodium 250mg
Boswellia Serrata /Indian Frankincense/ 60%extract 250mg
White Willow Bark 15% extract 100mg
Turmeric root / 95% extract curcumin / 50mg
Devilʼs Claw /root/ extract 30mg

Potent mixture of botanical extracts , glucosamine and chondroitin sulfate for healthy joints support. all these ingredients , tested in clinical trials have proved to reduce various inflammatory cytokines, therefore able to block pain, decrease swelling of joints and able to increase functionality of joints /ref 1,2,3,4 / they supported healthy anti-oxidants level and redox balance in joint tissues and showed to have protective effect on jointʼs cartilage /ref2,3/

1.BOSWELLIA SERRATA used for centuries in Ayurveda medicine for treatment of inflammatory conditions particularly arthritis / ref4/. Boswellia serrata / BS/ as shown in studies was able to hinder cartilage breakdown by metalloproteinase-3 / MMP-3/ and to block Intercellular Adhesion Molecule 1/ ICAM-1/ and thereby hinder inflammatory reactions. /ref 2/ Human clinical studies showed “trends of benefits “when used for treatments of OA coupled with a low burden of side effects, superiority compared to placebo in reducing pain and increasing functionality, studies done on patients with knee OA demonstrated that phytopreparations from BS gum resin are able to reduce pain and increase functionality after only a few days/ a week or so at most/ with no serious adverse effects. A phytosomal Boswellia preparation has been shown to be beneficial in the treatment of knee OA when added to the standard management of this condition . It also hasten functional recovery and diminished pain and objective physical and humoral signs of inflammations in persons with arthritis of the hand induced by work-related overstraining . A combination of Curcuma longa and BS was proven to be safe and efficient in patients with osteoarthritis, alleviating symptoms and objective signs, even better than celecoxib (a selective COX-2 inhibitor) and being practically devoid of side effects /. ref 5/

2.CURCUMIN is a phenolic phytochemical extracted from turmeric/ Curcuma Longa/ an herb extensively used in Chinese and Auyrvedic herbology for variety of
complaints, with increasing use for its cell protecting and immunomodulatory properties. Research has demonstrated that curcumin has antioxidant activity , it is an immune cell modulator and has inhibatory effect on COX-2 , iNOS enzymes , TNF-alfa , IL and NFkB./ references 6,7 / Various animal and human studies support its use in promoting health in joints, gastrointestinal mucosa, the eye’s uveal tract, liver detoxification pathways. Curcumin may support balanced immune response in cardiovascular, nervous, gastrointestinal , respiratory tissues. / References ,6,7,8,12,/ In animal studies curcumin promoted normal cell proliferation due to its ability to modulate certain types of cytokines/ like NF-kB transcription factor/, support detoxification, scavenge free radicals and to support induction of cell cycle arrest and apoptosis./Reference 6,7,8,9,10 11,12,13,14 / Previous observational studies in populations that consume large amounts of curry, as well as laboratory research on rodents , have strongly suggested that curcumin might be effective in preventing and/or treating cancer in the lower intestine/ref 15,16 /

3.DEVIL’S CLAW ROOT EXTRACT / Harpagophytum procumbens/ Human studies showed that various parts of Devil’s Claw tuber extract, equivalent to 50-60 mg of harpagoside daily administered for 8-16 weeks significantly improved the clinical picture of subjects with knee and hip Osteoarthritis in terms of pain, movement limitation and joint crepitus /Ref 17,18 / Studies suggests that harpagoside exerts a significant anti-inflammatory effect by inhibiting the inflammatory stimuli mediated by suppressing c-FOS/AP-1 activity in OA chondrocytes under pathological conditions / Ref 19./ In animal studies it in animals with induced bone loss oral administration of harpagide significantly improved recovery of bone mineral density, and architecture of bone Harpagide effectively inhibited the serum levels of biochemical markers of bone loss, including alkaline phosphatase, osteocalcin, C-terminal telopeptide, and tartrate-resistant acid phosphatase., so it may be bioactive compound with potential for improvement of age-dependent bone destruction disease /ref 20/

4.WHITE WILLOW BARK /Salix alba/ has been used for centuries to help minor aches and pain . Studies showed that active ingredient of willow bark salicin effects cytokine balance and helps to relieve joints discomfort / ref 21, 22/

REFERENCES

1.Sengupta K, Krishnaraju A.V. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee .A double blind , randomized placebo controlled clinical study . Int.J.Med.Sci, 2010

2.Blain E.J. Ali A.Y. Duance V.C. Boswellia fiereana/ frankinsence/ suppresses cytokine induced matrix metaloproteinase expression and production of pro-inflammatory molecules in articular cartilage Phyt. research 2009

3.CameronM, Chrubasik S, Oral therapies for treating oA

4.Ammon Boswelic acid as an active principle in treatment of chronic inflammatory disease.

5. Phytomedicine in Joint Disorder Dorin Dragos, et all Human clinical studies. A Cochrane systematic review concluded that preparations from BS “show trends of benefits” (when used for the treatment of OA) coupled with a low burden of side effects, citing two high-quality and two moderate-quality studies demonstrating superiority compared to placebo in reducing pain and increasing functionality, and a moderate-quality study indicating a favorable adverse events profile ]. Indeed, a couple of double-blind, randomized, placebo-controlled studies done on patients with knee OA demonstrated that phytopreparations from BS gum resin are able to reduce pain and increase functionality after only a few days (a week or so at most) with no serious adverse effects . A phytosomal Boswellia preparation has been shown to be beneficial in the treatment of knee OA when added to the standard management of this condition (ameliorating the functional status (higher Karnofski Scale Index) and the symptoms (lower WOMAC (Western Ontario and McMaster Universities questionnaire) Score) . Human clinical studies. A Cochrane systematic review concluded that preparations from BS “show trends of benefits” (when used for the treatment of OA) coupled with a low burden of side effects, citing two high-quality and two moderate-quality studies demonstrating superiority compared to placebo in reducing pain and increasing functionality, and a moderate-quality study indicating a favorable adverse events profile [35]. Indeed, a couple of double-blind, randomized, placebo-controlled studies done on patients with knee OA demonstrated that phytopreparations from BS gum resin are able to reduce pain and increase functionality after only a few days (a week or so at most) with no serious adverse effects [31,36]. A phytosomal Boswellia preparation has been shown to be beneficial in the treatment of knee OA when added to the standard management of this condition (ameliorating the functional status (higher Karnofski Scale Index) and the symptoms (lower WOMAC (Western Ontario and McMaster Universities questionnaire) Score) [37]). It also hasten functional recovery and diminished pain and objective physical and humoral signs of inflammations in persons with arthritis of the hand induced by work-related overstraining [38]. A combination of Curcuma longa and BS was proven to be safe and efficient in patients with osteoarthritis, alleviating symptoms and objective signs, even better than celecoxib (a selective COX-2 inhibitor) and being practically devoid of side effects [39]. However other studies failed to confirm the efficiency of BS in the treatment of active RA [40]8.

6..Jagetia GC, Aggarwal BB “Spicing up” of the immune system by curcumin J.Clin Immunol. 2007 Jan;27 (1)19-35 PMID 17211725

7.Sun AY, Wang Q, Simonyi A at al, Botanical phenolics and brain health ,Neuromolecular Med. 2008 10(4); 259-74 PMID 1919103911.

8. Neelofar,K, Shreaz S, Rimple B,et al Curcumin as a promising anticandidal of clinical interest Can J Microbiol. 2011 Mar 57(3) : 204-10 PMID 2135876113Martins CW, da Silva DL, Neres AT et, Curcumin as a promising antifungal of clinical interest. J Antimicrob Chemother. 2009 Feb; 63(2):337 -39 PMID 19038979.

9.Ukil A, Maity S , Karmakar S et al Curcumin the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid induced colitis. Br J Pharmacol. 2003 May 139(2):209-18. PMID 12770926.

10.Epstein J, Docena G, McDonald TT,et al. Curcumin suppresses p38 mitogenactivated protein kinase activation, reduces IL-1 beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr.2010 March ;103 (6):824-32 PMID 19878610.

11. Funk JL, Oyarzo JN , Frye JB et al., Turmeric extract containing curcuminoids prevent experimental rheumatoid arthritis . J Nat Prod.2006 Mar;69(3) 351-55 PMID 16562833.

12.Holt PR, Katz S ,Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005 Nov;50(11):2191-93 PMID 16240238.

13. Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis . Phytother Res 1999 June 13(4) 318-22 PMID 10404539. DhillonN, Aggarwal BB,Newman RA ,et al . Phase II trial of curcumin in patients with advanced pancreatic cancer . Clin Cancer Res. 2008 Jul; 14(14) 4491-99. PMID 18628464 Xie L , Li XK,Takahara S, Curcumin has bright prospects for the treatment of multiple sclerosis. Int Immunopharmacol. 2011 Mar; 11(3);323-30 /20828641/

14..Mythri RB Harish G, Dubey SK ,et al. Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrate-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson’s disease. Mol Cell Biochem .2011 Jan ; 347(1-2)135-43.PMID 20972609.

15.. RavindranJ, Prasad S, Aggarwal BB, Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 2009 Sep; 11(3) :495-510 PMID 9619120.

16.Goel A Aggarwal BB. Curcumin , the golden spice from Indian saffron , is a chemoensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 2010 Oct;62(7):919-30. PMID 20924967

17.Wegener, Luepke, Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil’s claw , Phytotherapy Research 2003

18.Chrubasik S, Tharmer J, Comparison of outcome measures during therapy with the proprietary HP extract dolotefin in patients with pain in the lower back ,knee or hip.

19.Haseeb A, Ansari MY Haqqi TM Harpagoside supresses IL-6 expression in primary human osteoarthritis chondrocytes .2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:311-320, 2017.

20.Chung HJ, Kyung Kim W, Joo Park H, Cho L, Kim MR Anti-osteoporotic activity of harpagide by regulationof bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse model J.Ethnopharmacology 2016 Feb17 PMID26712566

21.Singh AP Salicin-A natural analgesic. Ethnobotanical Leaflets 2003 22.Flebich BL, Appel K Anti-inflammatory effects of willow bark extract.Clin Pharmacol Ther. 2003 Jul