HERICINEX MCT Capsules
HERICIUM ERINACEUS 20% polysaccharides extract
aka LIONʼS MANE MUSHROOM 410mg
POLYGALA TENUIFOLIA 20:1 extract 80mg
MCT powder 160mg
Powerful combination promoting Neuronal Health and cognition.
Hericium Erinaceus /aka Lionʼs mane mushroom , Yamabushitake mushroom/ is an edible mushroom known to Asians for its many biological activities especially promoting health of neurons in the brain and peripheral nerves.
Recent clinical studies discovered Hericium Erinaceus ability to induce production of Nerve Growth Factor in the brain and peripheral nervous system./ref 1.5/ NGF is one of neurotrophins that plays an important role in protection repair and regeneration of neurons.
Extract from Hericuim Erinaceus support healthy cognition and memory as demonstrated in clinical human studies /ref6/
Hericium Erinaceus extract support healthy neurons by protecting them from oxidative stress, damage from amyloid plaque accumulation and neuronal death./ref 2,7,3/
Hericium Erinaceus provides a signiﬁcant support in healthy lipid metabolism, glucose regulation and immune system enhancement.
Polygala Tenuifolia extract according to recent clinical studies signiﬁcantly lowered scopolamine induced cognitive impairment in rats , Polygala Tenuifolia extract (BT11) “ signiﬁcantly reduced neurotoxicity induced by glutamate and toxic metabolites of APP (amyloid precursor proteins) as A Beta (Amyloid Beta) an C-terminal fragments of APP in primary cultured neurons in rats.”
Pretreatment with Polygala B-11 extract greatly reduced neuronal cells death induced by glutamate. Many clinical studies utilizing Polygala dry root extract has shown signiﬁcant neuroprotective and cognition enhancing properties. Those new ﬁndings suggest that Polygala Tenuifolis exhibits protective action against neuronal death and cognitive decline in Alzheimer disease (AD) and other neurodegenerative diseases caused by neurotoxicity and cholinergic disfunction. /Ref 10,11/
MCT/ Medium ChainTriglycerides / extract from coconut oil , enhances ketones production which is an excellent fuel for the brain cells, supports health and functions of neurons./ Ref 8,9 /
1 . Kavagishi H, Ando, M, Sakamoto, H. et al HericinonesC, D, AND E, stimulators of nerve growth factor synthesis, from the mushroom Hericium erinaceum. Tetrahedron Lett 1991, 32(35) 456-4
2. Hsing-chun Kuo, Hericuim erinaceum mycelia and its isolated erinacine A protection from MPTP- induced neurotoxicity through stress triggering an apoptosis cascade. Journal of Translational Medicine, PMCID PMC 4977317
3.Mori K., Obara Y., Moriya T., Inatomi S., Nakahata N., E ffectnofnHericuim erinaceum on amyloid B (25-35) peptide induced learning and memory deﬁcitsin mice PMDID 21383512
4.Cheng JF Tsai CL, Lien YY, Lee MS, Sc High Molecular weight of polysaccharides from Hericium erinaceus against amyloid beta induced neurotoxicity PMID 27266872
5.K Mori , Y. Obara , M.Hirota , Y. Azumi, S. Kinugasa S. S. Inatomi N. Nakahata Hericium erinaceum exteract induced NGF m RNA expression in 132 INS human astrocytoma cells “oral administration of H. erinaceum increased NGF mRNA expression in mouse hippocampus”
6. Mori K. Inatomi S. Ouchik , Y. Azumi Y, Tuchida T Improving effect of the mushroom Yamabushitake (Hericium erinaceum) on mild cognitive impairment: double blind placebo control clinical trial PMID 18844328
7.Kam-Fai Lee, Liann-Hwa Chen, chih -Chuan Teng, Chien-Heng Shen, at al Protective Effect of Hericium erinaceum mycelium and its isolated Erinacne A against ischemia injury induced neuronal cells death via inhibition of i NOS/ p 38 MAPK and Nitrotyrosine
8. Hertz L, Chen Y, Waagepetersen HS Effect on ketone bodies in Alzheimer Disease in relation to neural hypometabolism, B-amyloid toxicity and astrocyte function PMID 25832906
9.Pilot feasibility and safety study examining effect of MCT supplement in subjects with mild cognitive impairments: A randomized controlled trial “ Results: Intake of MCT oil increased serum ketone bodies and improved memory while intake of placebo did not show improvements in any of cognitive measures tested.
10.Cheol Hyuong Park, . Se Hoon Choi, Ja-Wook Koo,. You Hun Suh,.Ji-Heui Seo,. Hye- Sun kim, Sun- Jin Jeon. Novel cognitive improving and neuroprotective activity of Polygala Tenuifolia willdenow extract, BT-1