DOLOREX – optimal non addictive analgesic and anti-inﬂammatory support.
Active ingredients: Rhizoma Corydalis (Yanhuso), Peonia Alba (Baishao) , Shefﬂera Arboricola , Devilsʼc Claw.
RHIZOMA CORYDALIS (Yanhuso) – known for centuries in TCM (Traditional Chinese Medicine) as a very effective pain treatment and blood circulation enhancing herb. It contains many bioactive alkaloids ; D-corydaline, L-tetrahydropalmitine, Corydalis I, Ltetrahydrocoptisine, L-tetrahydrocolubamine to name a few. The one of the most abundant of them is Tetrahydropalmitine. Tetrahydropalmitine not only acts as a potent pain remedy but according to recent studies may be very effective in treatment of cocaine and heroine addiction.Studies conducted in China by the team of researchers led by Dr Jin Guozhang at Shanghai Medical Institute provided this evidence.L-Tetrahydropalmitine (L-THP) binds to D1 and D2 dopamine receptors and is an antagonist to both of them. L-Tetrahydropalmitine may be an effective tool to reduce drug craving and relapse, promote detoxiﬁcation and addiction relapse.
1.Anonymous Yanhuso Pharmacopoeia of Peopleʼs Republic of China 2000; I : 108-108
2.Yang Z. Shao YC, Li SJ. Qi JL, Zhang MJ, Hao W, Jin GZ Medication of L-tetrahydropalmitine signiﬁcantly ameliorate opiate craving and abstinence rate in heroine users: a pilot study. Acta Pharmacologica Sinica ; 2008; 29: 781-788 ( PMC fre article pub Med
3. Maarcenac F, Jin GZ, Gonan F. Effect of L-Tetrahydropalmitine on dopamine metabilism in the rat striatum. Psychopharmacology . 1986; 29: 527-534 Pub Med
PEONIA ALBA Radix (Baishao) – has been used in China, Korea and Japan to treat rheumatoid arthritis, dysmenorrhea, muscles cramps and spasms, hepatitis and many more inﬂammatory and pain conditions for more than 1000 years. Water /ethanol extract of Peonia Alba Radix is called Total Glucosides of Peony (TGP). TGP contains over 15 glucosides , the most abandon of then are Peonﬂorin and Albiﬂorin. Analgesic effect of TGP was observed in many animal studies. Anti-inﬂammatory effect of TGP was conﬁrmed in animal in vivo and in vitro studies.TGP inhibited acute and subacute inﬂammation by suppressing production of Prostaglandin E2, Leukotriene B4 and Nitric Oxide by reducing intracellular calcium ions concentration.
1.Cao Zang., Liu J., Peng X., Lu D., Qi R., Wang Y., Wang H., (2011) Peoniﬂorin improves survival inLPS – challenged mice through suppression of TNF Alpha , and IL 1 Beta release and augmentation of IL 10 production.
2.Cao C., W Y., Wang Y., You J., Pan H., Cao L., Liang R. 2002 Anti-inﬂammatory and analgesic effects of total glucosides of peonia injection. Zhong Yao, Xin Yao, Yu Lin, Chuang Yao, Li 13, 163-165 (in Chinese).
SHEFFLERA ARBORICOLA– well known in TCM (Traditional Chinese Medicine) as a remedy to promote blood circulation and relieve pain . Shefﬂera contains variety of pytochemicals including Gammahyhroxybutiric and Fumaric acid , 4 Acetoxy-3,5,4ʻ bibenzyl derivative from Shefﬂera was effective to inhibit activity of NFKappa B . Modern uses of Shefﬂera include treatment for rheumatoid arthritis , , numbness, abdominal pain, headaches, arthralgia, sore and swollen throat . It is also known to relieve symptoms of asthma . It can be used externally to treat bleeding and injuries.
1. Chen JK., Chen TT. Medical Herbology and Pharmacology City of Industry, CA Art of Medicine Press 2004 p. 314-315 2.Hou D., Zhong Hui R . Separation and determination of chemical constituents in volatile oils of three Chinese crude drugs. J. Pharm Biomed September 1998: 17; (8): 1423-6
DEVILʼS CLAW ROOT EXTRACT / Harpagophytum procumbens/ Human studies showed that various parts of Devilʼs Claw tuber extract, equivalent to 50-60 mg of harpagoside daily administered for 8-16 weeks signiﬁcantly improved the clinical picture of subjects with knee and hip Osteoarthritis in terms of pain, movement limitation and joint crepitus /Ref 1,2 / Studies suggests that harpagoside exerts a signiﬁcant anti-inﬂammatory effect by inhibiting the inﬂammatory stimuli mediated by suppressing c-FOS/AP-1 activity in OA chondrocytes under pathological conditions / Ref 3 / In animal studies it in animals with induced bone loss oral administration of harpagide signiﬁcantly improved recovery of bone mineral density, and architecture of bone Harpagide effectively inhibited the serum levels of biochemical markers of bone loss, including alkaline phosphatase, osteocalcin, C-terminal telopeptide, and tartrate-resistant acid phosphatase., so it may be bioactive compound with potential for improvement of age-dependent bone destruction disease / ref 4/
1.Wegener, Luepke, Treatment of patients with arthrosis of hip or knee with an aqueous extract of devilʼs claw , Phytotherapy Research 2003
2.Chrubasik S, Tharmer J, Comparison of outcome measures during therapy with the proprietary HP extract doloteﬁn in patients with pain in the lower back ,knee or hip.
3.Haseeb A, Ansari MY Haqqi TM Harpagoside supresses IL-6 expression in primary human osteoarthritis chondrocytes .2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:311-320, 2017.
4. Chung HJ, Kyung Kim W, Joo Park H, Cho L, Kim MR Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomyinduced bone loss mouse model J.Ethnopharmacology 2016 Feb17 PMID26712566