CURCUMIN is a phenolic phytochemical extracted from turmeric/ Curcuma Longa/ an herb extensively used in Chinese and Auyrvedic herbology for variety of complaints, with increasing use for its cell protecting and immunomodulatory properties.
Research has demonstrated that curcumin has antioxidant activity , it is an immune cell modulator and has inhibtory effect on COX-2 , iNOS enzymes , TNF-alfa , IL and NF-kB./ references 1,2 / various animal and human studies support its use in promoting health in joints, gastrointestinal mucosa, the eye’s uveal tract, liver detoxification pathways.
Curcumin may support balanced immune response in cardiovascular, nervous, gastrointestinal , respiratory tissues. / References 1,2,8,9,10,11,12. In animal studies curcumin promoted normal cell proliferation due to its ability to modulate certain types of cytokines like NF-kB transcription factor, support detoxification, scavenge free radicals and to support induction of cell cycle arrest and apoptosis./Reference 2,3,16,17.
Previous observational studies in populations that consume large amounts of curry, as well as laboratory research on rodents , have strongly suggested that curcumin might be effective in preventing and/or treating cancer in the lower intestine CURCUMIN MCT (reference 18). Neurons are very susceptible to oxidative stress due to high demand for oxygen, high level of polyunsaturated fatty acids in neuronal membrane phospholipids and low antioxidant defenses.
New research supports protective effect on neurons, and positive effect on brain’s amyloid plaques (reference 4).
Curcumin has been used for supporting healthy gut flora balance (reference1,2,6,7).
Cumin is a phytochemical extracted from Black seed (Nigella Sativa) which shows significant anti-inflammatory , anti-osteporotic (reference 3) , modulating and supporting immune regulation in preclinical trials (reference 5).
Piperine is an extract from black pepper fruit, which is a potent enhancer of absorption. Curcumin extract is poorly absorbed from gastrointestinal tract. Piperine increases the bioabsorption of curcumin by 2000% therefore increasing the amount of bioavailable curcumin in the blood. At a dose of 2g curcumin alone serum levels were very low or undetectable in humans volunteers but addition of piperine produced much higher serum concentration from 0.25 one hour after administration of curcumin and piperine together. (reference 1)
MCT / Medium Chain Triglycerides – fuel for neurons / nerve cells in brain/ when brain is starving, because brain can not utilize glucose any more and glucose can not get into the cell, neurons are dying . Unfortunately this leads to impairment of neurological functioning like memory impairment, speech , movement control etc. MCT intake improved memory in patients in clinical studies (ref 19, 20).
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18. In the study, published in the August issue of Clinical Gastroenterology and Hepatology, five patients with an inherited form of precancerous polyps in the lower bowel known as familial adenomatous polyposis, of FAP, were treated over an average of six months with regular doses of curcumin, the chemical found in turmeric, and quercetin, an antioxidant in onions. The average number of polyps dropped 60.4 percent, and the average size dropped by 50.9 percent, according to a team led by gastroenterologist Francis M. Giardiello, a professor at the School of Medicine, and Marcia Cruz-Correa, a visiting professor from the University of Puerto Rico School of Medicine. “We believe this is the first proof of principle that these substances have significant effects in patients with FAP,” Giardiello said. Familial adenomatous polyposis is a disorder that runs in families and is characterized by the development of hundreds of colorectal adenomas (polyps) and eventual colon cancer. Recently,
nonsteroidal anti-inflammatory drugs, known as NSAIDs, have been used to treat some patients with this condition, but these compounds often produce significant side effects, including gastrointestinal ulcerations and bleeding.
19. Rebello CJ, Keller JN, Liu AG, Johnson WD , Greenway FL; Pilot feasibility and safety study examining the effect of MCT supplementation in subjects with mild cognitive impairment .A randomized controlled trial “ Intake of MCT oil increased serum ketone bodies and improved memory, while
intake of placebo didn’t show any improvements in cognitive measures tested” PMID 26675661
20 .Roger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S; Effect of beta-hydroxybutyrate on cognition in memory-impaired adults “ketone bodies are an effective alternative energy substrate for the brain.Elevation of plasma ketone bodies through oral dose of MCT ( Medium Chain Tryglicerides) may improve cognitive functioning in older adults with memory disorders PMID 15123336